Ritonavir or lopinavir/ritonavir enormously raise plasma concentrations of oxycodone in healthier human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin greatly lessens plasma concentrations of oxycodone resulting from potent induction of CYP3A4.Opioid drugs really should not be your initially choice for ache proce